The Offshore Voyaging Reference Site

Antiseasickness Product Hurl-off, Our Drug Of Choice

Despite the solid win for Stugeron in our informal survey, I have had better luck with Gravol, which is available over the counter in most countries including Bermuda, Canada and the UK, but not the USA. I suspect that this exception is more to do with drug company marketing issues rather than regulatory ones since the active ingredient in Gravol is Dimenhydrinate, the same as that in Dramamine, which is available in the USA without prescription.

Our reasons for preferring Gravol are as follows:

  1. It does not seem to delay the onset of natural immunity to seasickness the way that Stugeron does. In fact my experience has been quite the opposite in that, although I have not taken it for years, in the past I have found that a single Gravol taken just before going off watch promotes a deep sleep from which I have awakened completely cured for the rest of the voyage, even if I was suffering mightily before hitting the sack. Of course this presupposes that you can keep the pill down long enough for it to kick in—but read on.
  2. Gravol comes in time release capsules, as far as I know the only anti-seasickness drug that does, which seems to make it work more effectively than Dramamine.
  3. Gravol is also available in suppository form. I have only had one experience with these, second hand I’m pleased to say, when a crew on Morgan’s Cloud, after being violently sick for three days to the point that he was becoming dangerously dehydrated (despite taking Stugeron), was completely cured by a single Gravol suppository.

Of course Gravol is, like all drugs, not without side effects, the most common being extreme drowsiness and dry mouth. The former can be bad enough, particularly with suppository use, to render a crew member non-functional. The good news is that, as we understand it, Dimenhydrinate is one of the safest of all the drugs for seasickness available.

More Articles From Dealing With Seasickness:

  1. Real World Test of Relief Band For Seasickness
  2. Antiseasickness Product Hurl-off, Survey Winner
  3. Antiseasickness Product Hurl-off, Our Drug Of Choice
  4. Don’t Pass The Bucket, Please!
  5. Seasickness Revisited
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Bruce Cuthbert

I would not sail without Promethazine [i.m injection] ampoules.
They are very useful when someone feels sick /vomiting, as tablets will not be absorbed by the stomach then. 12.5mg works for me, drowsiness is manageable but is usually significant at bigger doses. [Probably good for the severely affected.]
Clearly one needs to be able to give an injection to use this.
This has been the preferred drug for astronauts, an activity which apparently makes almost everyone sick.
That said ,there is no perfect drug – Stugeron makes me nauseated on land.

Matthew Rhames

My wife and I always pack Zofran oral dissolving tablets, also sold as Ondansetron. We are both ER physicians so it makes it easier. It is a very mild medication, no drowsiness side effects like antihistamines cause ie Dramamine. You can pretty much clear up nausea in anyone child or adult safely with one or two doses. In additions, Promethazine aka Phenergan is a drug we almost never use anymore because of the side effects, drowsiness, dystonia, and even seizures. If possible I would suggest you giving Zofran (Ondansetron) a try after a discussion with your physician.

Matthew Rhames

John in the USA its RX only. Coen, below, makes some very salient points, there is no good data on motion-induced nausea and vomiting and Zofran. It was developed to treat toxin-induced (stomach bug or chemotherapy caused) nausea and vomiting. I, my wife and daughters have used it exclusively and successfully for motion sickness but that should not be interpreted as a panacea for all. My only hesitance with Phenergan (which I sure have used a ton of in the past) are the side effects.


Hi Matthew,

I used to be an ER physician myself and tried ondansetron on a number of occasions. Used to do a lot of kayak fishing of the Western Australian coast. My experience with this was dismal, I suspected that my seasickness may have been worse. What literature I could find at the time seemed to indicate that it wasn’t effective for motion sickness. I haven’t looked into this recently, though. It is such an individual thing that it may very well be helpful for some


Matthew Rhames

There is no ” I used to be” for ER Docs you’re one forever!
I do not like Phenergan as it has too many bad side effects. I am sure you have had patients just like I have had, who got it IM and went bonkers with dystonia, akathisia and worse. Recently we were in a moderate swell off the east of the Bahamas on a Morgan 41 classic. It was increasingly swelly and pretty soon all of us were feeling green. 4 out of 5 of us took Ondansetron, the 5th person puked for a few hours and got better. I agree Phenergan aka Promethazine is a much better anti-emetic, I just am hesitant to use it on a boat at sea. We had good results with Zofran but there are limited studies on it, and so far those limited studies do not show benefit. It could have just been a placebo effect for us, but it worked. I only recommend it as something to try prior to the IM Phenergan.


I agree on the phenergan and used that once many years ago. It took me 2 days to get over the drowsiness. So far I have not found anything that really helps me, except being on deck at the wheel, so if ondansetron works for you thank your lucky stars and keep using it. So far at least it appears to be very safe with few significant side effects. I don’t think we will find a single solution that works for everyone

Brian Sutton

Bonine (meclizine) works very well for me with no side effects! Sold over the counter in the US for motion sickness.When things get really rolly I will get sick and stay sick as long as things stay rolly if I don’t take it.Dramamine does not work for me and just puts me to sleep.